Background: Obesity and type 2 diabetes can impair the function of important cellular pathways. Activation of the mTOR pathway results in regulation of the SREBP1 protein for metabolism and regulation of adipose tissue. The aim of this study was to investigate the effect of 4 weeks of high intensity interval training on the content of mTOR and SREBP1 in adipose tissue of type 2 diabetic rats. ...

Background: mTOR and CREB proteins are two important factors in cellular pathways and regulating fat tissue metabolism. Therefore, the aim of this research is the effect of endurance training on the amount of mTOR and CREB proteins in the adipose tissue of type 2 diabetic rats. Methods: In this experimental study, 18 rats 2-month-old male Sprague-Dawley rats with a mean weight of 270±20g were ...

Mammalian mechanistic target of rapamycine (mTOR) is a conserved serine/threonine kinase in the cellular PI3K/Akt/mTOR signaling pathway. This pathway is modified by cellular alterations such as level of energy, growth factors, stresses, as well as the increased environmental level of cancerous cytokines. In general, increase of this kinase protein function is seen in various types of cancers, ...

Background: The pathway of mTORC1 is one of the most important pathway in protein synthesis, and type 2 diabetes and insulin resistance can lead to inhibit this pathway. The aim of this study was to investigate the effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways in gastrocnemius muscle in type 2 diabetic rats. Materials and met...

Background and Objectives: The most important mechanism of protein synthesis muscle is the mTORC1 pathway in skeletal muscle in which very important proteins play role. Diabetes disturbs this pathway through generating resistance to insulin. The effect of high intensity interval training (HIIT) has not been studied yet on this important pathway in type 2 diabetes. Therefore, the purpose of the ...

Introduction: The mTOR pathway in skeletal muscle plays a very important role in the protein synthesis process, which plays a very important role in proteins. The role of endurance exercise has not yet been studied in this important pathway in protein synthesis in people with type 2 diabetes. The purpose of the present study was to investigate the effect of 8 weeks endurance training on the con...

Background: The mTORC1 pathway is one of the important pathways for protein synthesis in the heart, which can lead to physiological or pathological hypertrophy. Diabetes can lead to defects in this pathway. The aim of this study was to examine the effect of 4 weeks’ aerobic training on the content of mTORC1 signaling pathway proteins in heart tissue of type 1 diabetes rats. Methods: In this ...